Alzheimer's Association International Conference (AAIC) 2024
Sep 19, 2024 · Are Alzheimer’s Blood Tests Ready for Primary Care? Add To My AlzForum; 09 Aug 2024. Plasma p-tau217/tau217, alone or with Aβ42/40, identified people with amyloid pathology more accurately than did expert clinical assessment.
ALZFORUM | NETWORKING FOR A CURE
3 days ago · A proposal that regulators approve Alzheimer’s immunotherapies based on biomarkers prompted spirited discussion on Alzforum, with 25 comments from around the world and two successive responses by the proposal’s corresponding author Dennis Selkoe.This, in turn, inspired an exchange of Open Letters between Scott Small and Selkoe. The latter is closed; the original debate remains open.
Databases - ALZFORUM
AlzAntibodies. This database aims to provide detailed descriptions of selected antibodies related to the study of Alzheimer’s disease. AlzBiomarker
VG-3927 | ALZFORUM
Aug 5, 2024 · Overview. Name: VG-3927 Therapy Type: Small Molecule Target Type: Amyloid-Related , Inflammation Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 1) Company: Vigil Neuroscience, Inc. Background. VG-3927 is a brain-penetrant, small-molecule agonist of the TREM2 receptor on microglia. TREM2 activation stimulates proliferation and phagocytic function of microglia ...
5xFAD (C57BL6) - ALZFORUM
Apr 9, 2019 · Species: Mouse Genes: APP, PSEN1 Mutations: APP K670_M671delinsNL (Swedish), APP I716V (Florida), APP V717I (London), PSEN1 M146L (A>C), PSEN1 L286V Modification: APP: Transgenic; PSEN1: Transgenic Disease Relevance: Alzheimer's Disease Strain Name: B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax Genetic Background: C57BL6 Availability: Available from The Jackson Laboratory, JAX MMRRC ...
CT1812 | ALZFORUM
Nov 9, 2024 · Overview. Name: CT1812 Synonyms: Elayta Therapy Type: Small Molecule Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 2) Company: Cognition Therapeutics Inc. Background. CT1812 is a small-molecule antagonist of the sigma2 receptor. The rationale behind this therapeutic approach is that ligands for the sigma2 receptor complex are ...
Minzasolmin - ALZFORUM
Overview. Name: Minzasolmin Synonyms: UCB0599, NPT200-11 Chemical Name: N-[(2R)-1-(1H-indol-3-yl)hexan-2-yl]-2-(4-methylpiperazin-1-yl)-1,3-thiazole-5-carboxamide Therapy Type: Small Molecule Target Type: alpha-synuclein Condition(s): Parkinson's Disease U.S. FDA Status: Parkinson's Disease (Phase 2) Company: Neuropore Therapies, Inc., Novartis Pharmaceuticals Corporation, UCB S.A.
ALZ-801 | ALZFORUM
Sep 23, 2024 · Overview. Name: ALZ-801 Synonyms: valiltramiprosate, NRM-8499, homotaurine prodrug, 3-APS Therapy Type: Small Molecule Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 3) Company: Alzheon Inc. Background. This is a prodrug of homotaurine, a modified amino acid previously developed under the names tramiprosate and Alzhemed™.
Trontinemab - ALZFORUM
May 9, 2024 · Overview. Name: Trontinemab Synonyms: RO7126209, RG6102 , Brain shuttle gantenerumab Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 1/2) Company: Hoffmann-La Roche Background. RO7126209 is a new version of the anti-amyloid monoclonal antibody gantenerumab, engineered to more easily cross the blood ...
Remternetug - ALZFORUM
Overview. Name: Remternetug Synonyms: LY3372993, N3pG-Abeta mAb Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 3) Company: Eli Lilly & Co. Background. Remternetug, previously LY3372993, is an investigational monoclonal antibody. Lilly's development pipeline lists it as an N3pG-Aβ mAb, suggesting ...