Eosinophilic esophagitis (EoE) is a chronic esophageal inflammatory disease of undetermined pathophysiology that results in dense mucosal eosinophilia and esophageal dysfunction. In childhood ...

3 University of Colorado School of Medicine, Aurora, Colorado, USA Objective Eosinophils reside in the colonic mucosa and increase significantly during disease. Although a number of studies have ...

Objective Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and ...

Objective: Eosinophils are hallmarks in allergic type 2 inflammation and are known to release cytotoxic granule proteins that contribute to inflammation. Eosinophils develop in the bone marrow from ...

impact on tissue health (histology) as measured by EoEHSS, and the measurement of peak eosinophil count ("PEC"). "In the RESOLVE trial, positive efficacy and safety outcomes continue to be observed," ...

impact on tissue health (histology) as measured by EoEHSS, and the measurement of peak eosinophil count ("PEC"). "In the RESOLVE trial, positive efficacy and safety outcomes continue to be ...

Background & Aims: Eosinophils are the main inflammatory effector cells that damage gastrointestinal tissue in eosinophilic gastrointestinal diseases (EGIDs). Activation of the OX40 pathway aggravates ...

We are also interested in the pronounced tumour heterogeneity associated with CCRCC. Along these lines we are studying CCRCC with eosinophilic histology. A third area of research addresses the ...