Objective The Lupus Clinic at University College London Hospital (UCLH) has been recruiting patients since 1979.We carried out a comprehensive study of the records of patients from the clinic to study ...

Chimeric antigen receptor (CAR) T cells directed against CD19 have demonstrated efficacy in treating active lupus in both human and mouse lupus. However, a significant limitation of this approach is ...

Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare immune-mediated neurologic disorder that targets the peripheral nerves and nerve roots which can cause progressive ...

Methods Two hundred-eleven SLE patients were included in a retrospective cohort study. Participants were divided into 2 groups, SDI = 0 (without damage) or SDI ≥ 1 (with damage), then the two groups ...

Background Systemic lupus erythematosus (SLE) is a female predominant autoimmune disorder. X chromosome contains the largest number of immune-related genes of entire human genome. The number of X ...

Background In our studies of the relationship of the association of Epstein-Barr virus (EBV) infection with SLE we have also found an association of the anti-EBV Epstein-Barr Nuclear Antigen 1 (EBNA1) ...

Background Leukocyte immunoglobulin-like receptor A3 (LILRA3) is the soluble protein of LILRs family. LILRA3 exhibits a 6.7-kb deletion variation among individuals. The deletion removes all of four Ig ...

Background Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by production of autoantibodies. The anti-double stranded DNA (anti-dsDNA) autoantibodies are ...

Objective Cognitive dysfunction is a characteristic yet heterogeneous feature of systemic lupus erythematosus (SLE) that can impact quality of life. In a phase 2 trial ( NCT03656562) comprising two ...

Objective (i) Assess a novel musculoskeletal SLE trial design with objective eligibility and endpoints and a low-glucocorticoid standard of care; (ii) further validate Lupus Arthritis and ...

Objective Systemic lupus erythematosus (SLE) is characterized by persistent stimulation of the adaptive immune response and oxidative stress from Reactive Oxygen Species (ROS) generation. Mitochondria ...

Abdelkefi Cherifa, P121Abdelkefi Cherifa, P121 Abdelmoumen Karim, P80 Abheiden Carolien, O7 Abid Yosr, P50 Abida Houssem, P32, P121 Abramova Nadezda, P102 Abramson Jeremy, P105 Abreu Catarina, O41 ...