We’ve been following the development of uniQure’s HTT-lowering drug, AMT-130, from its genesis in the lab, to animal studies just a few years ago, and now through to their ongoing Phase 1/2 clinical ...

Announcing the 2025 HDBuzz Prize for Young Science Writers – sponsored by the Hereditary Disease Foundation!

From vision changes to genetic traffic jams and a clinical trial update, May was full of HD science excitement! Dive into our latest roundup to see how researchers are advancing Huntington’s ...

In cells without the HD gene, HTT stimulates PARylation and promotes efficient DNA repair. However, in HD, the mutant HTT protein fails to stimulate PARP, leading to fewer PAR chains, impaired DNA ...

A recently published review discusses the challenges of dental care for people with HD, and the ways that informed dentists and medical teams can help to manage oral healthcare throughout the HD ...

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COVID-19 update: what does it mean for HD families, how does it impact HD research, and how has it changed the way science works? Wave Life Sciences announces that its antisense drug WVE-120102 has ...