Another wrong-way crash in the St. Louis region has left a young athlete fighting to recover. Tom Hanks ‘storms out’ of SNL ...

A coffee shop that’s also a branch of one of the nation’s biggest banks is among the new retail options at a St. Louis-area ...

Ladies and gentlemen, boys and girls, antique enthusiasts and curious cats alike, prepare yourselves for a journey through ...

The Missouri Historical Society has launched the “We Are St. Louis” campaign, designed to introduce people to a St. Louis ...

A Missouri judge on Friday blocked a licensing requirement for abortion clinics that providers argued was a key obstacle to ...

Scientists around St. Louis worry their medical research will lose key funding as the National Institutes of Health (NIH) announced changes on how finance grants can be ...

Approximately 143,688 people moved to Missouri in 2023, while 135,597 moved out. This represents a net gain of 8,091 ...

Happy hour at 5 p.m., followed by the program at 6:30 p.m. 5 On Your Side’s Kelly Jackson and Brent Solomon will be there to ...

A Tennessee-based paper company with facilities across the country has announced it will be closing its St. Louis facility and laying off over 70 employees.

Meteorologists warn that the coldest burst of Arctic air this season is coming to put an icy and prolonged exclamation point ...

The Republican bill was filed in response to a Kansas City ordinance passed last year that bans landlords refusing to lease ...

The proposed cap on grants is part of a raft of sweeping federal cost-cutting measures put in place by the Trump ...