While DNA sequencing is routine, determining protein sequences remains one of biology’s toughest challenges, says ...

AI systems already work their magic in many areas of biomedical science, helping to solve protein structure, discover hidden ...

Predicting a protein's structure from its amino acid sequence is a 'holy grail' for the structural biology community. In spite of decades of effort, it remains an extremely difficult problem both ...

Because a protein’s structure helps determine its biological function, the new structures, along with those available from cryo-EM, could revolutionize biology and drug discovery. To be useful ...

Learn about our Editorial Policies. While AlphaFold and the subsequent AI revolution in biology garnered a lot of attention, the foundational bricks for the strides made in protein structure and ...

The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

Our research focuses on studies on the molecular structure and mechanism of proteins, recently mostly on the endoplasmic ... We also collaborate on various structural biology projects with local ...

Rohini Subrahmanyam is a biologist-turned-science-writer with a background in neuroscience and developmental biology. She has written ... nanoseconds to microseconds for a protein to morph along its ...

Our structure reveals many new ways to change PINK1, essentially switching it on, which will be life-changing for people with Parkinson's." The PINK1 protein is an important maintenance worker in ...

"AlphaFold has transformed structural biology by providing accurate predictions of protein structures ... accurately predict the three-dimensional structure of IDPs, it can predict the distances ...

This unique structure was originally believed ... This new understanding of circRNAs as hidden protein sources represents a major shift in molecular biology and oncology. By further exploring ...