TOKYO — Doctors may eventually be able to tell whether your cells are aging prematurely without needles, blood tests, or expensive lab work. Japanese researchers have developed an experimental ...

The variety of blood cells decreases with age. Some are lost, while others become dominant, leading to a loss of functional diversity. This, in turn, weakens the immune system in older individuals and ...

In recent years, there has been a growing trend of an aging patient population and an increasing prevalence of age-associated diseases, underscoring the need for advancing research into the ...

For human health, prematurely aging cells are a big problem. When a cell ages and stops growing, its function changes, which can cause or worsen cardiovascular disease, Alzheimer's disease ...

Researchers from Osaka University found that knockdown of the Adaptor Protein Complex 2, Alpha 1 Subunit (AP2A1) rejuvenates aging cells, while AP2A1 overexpression ages young cells. AP2A1 appears ...

We find nuclear dynamics in vivo are further impacted by large organelles (phagosomes) and the plasticity of neighbouring cells, which themselves deform during leukocyte passage. The biomechanics of ...

Aging and its associated pathologies are overwhelmingly the next challenge in cardiovascular disease. Dysregulated mineral metabolism is emerging as a key driver of vascular aging. We show that loss ...

Age-related changes in breast luminal epithelial cells may drive some breast cancers and offer potential screening and prevention targets.

"These findings establish excessive nuclear lipid deposition as a key hallmark of aging, with profound implications for nuclear processes such as chromatin organization, DNA repair, and gene ...

“A consistent feature of aging across diverse species is the progressive accumulation of lipid droplets (nLDs) within the nuclear compartment, which disrupts nuclear architecture and ...

Mayo Clinic researchers have identified interleukin-23 receptor (IL-23R) as a significant biomarker of cellular senescence and aging in both mice and humans. Experiments show that IL-23R levels in ...