Thus, dividing cells have the capacity to clear protein aggregates to maintain proteostasis in the newly divided cells, which could have implications for human disease development and aging ... the ...

For human health, prematurely aging cells are a big problem. When a cell ages and stops growing, its function changes, which can cause or worsen cardiovascular disease, Alzheimer's disease and ...

"We also have shown that this pathway can be modified by existing drugs in cultured cells and mice, so it may be possible to one day design a treatment that targets p53 to promote healthier aging ...

As we age, telomere length naturally decreases. Over the course of a lifetime, telomere shortening instructs aging cells to stop dividing. This normally functions as a critical barrier to stop cancer.

Their findings, published in Small and Aging Cell, offer new insights that could pave the way for better treatments for osteoporosis and age-related bone loss. Osteocytes are the master regulators of ...

Increasing evidence indicates that as individuals age, certain mutations accumulate that are found in cancer cells. While these "initiated” cells behave essentially normally, they can propagate to ...

More information: Mark A. Sanborn et al, Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy, Nature Communications (2025). DOI: 10. ...

In a paper for Nature Communications, Mark Sanborn and co-authors from the College of Medicine announced the open-source tool to find aging - or senescent - cells in organs and tissues.

2025 — Older adults experience less muscle soreness following exercise according to research which overturns the widespread belief that aging muscles are ... Mar. 31, 2025 — New research ...