First-in-class oral selective SMARCA2 (BRM) inhibitor FHD-909 (LY4050784) continues enrollment in Phase 1 trial for SMARCA4 (BRG1) mutated ...

Pharmacodynamic and pharmacokinetic preclinical data demonstrate candidates: Are well tolerated in vivo with no observed decrease in platelet levels, and no effects on megakaryocyte viability at ...

present an important study that applied a high-resolution transposon-based barcoding system to show the clonal contribution of hematopoietic stem and ...

(1) We fully agree with the reviewer that the aged environment indeed would affect the myeloid and megakaryocyte differentiation behaviors of HSC. As a result, the clonal behaviors of HSCs presented ...

CD8 + T cells also suppress megakaryocyte apoptosis and then increase the number of dysfunctional megakaryocytes, leading to suppression of megakaryocyte maturation and platelet production. Tregs ...

With increasing public awareness of healthy lifestyles and evidence-based nutrition, Medicine and Food Homology (MFH), a traditional Chinese concept originating from Huangdi Neijing Taisu, posits that ...

The mechanism of thrombocytopenia during acute pulmonary hypertension (PH) decompensation may be partly due to platelet aggregation in the lung. Platelet aggregates in explanted lung from 16 lung ...