Researchers provide a conceptual overview of liver vasomics, including the classification of vascular phenotypes in the liver.   Chronic liver diseases are closely linked to complex hemodynamic ...

The adjacent liver cells were enlarged, with a clear cytoplasm containing vacuoles and coarse fragments of bile pigment, and in some of the cells fat droplets were observed. The sinusoids in the ...

Primary liver cancer is cancer that started in the liver. There are 5 main types. The type depends on the type of cell that the cancer started in. Primary liver cancer is different to cancer that ...

LSECs are lining the liver sinusoids, a position that puts them in direct contact with antigens in the blood. This location, combined with their extraordinary clearance and tolerogenic function ...

If you already have a liver condition such as cirrhosis, tell your doctor if you have any new or worsening symptoms. Symptoms of liver cancer are often quite vague and vary depending on where the ...

To prevent or treat these conditions through targeted immunotherapy, we developed a clinical-stage nanoparticle platform that leverages the tolerogenic capacity of liver sinusoidal endothelial cells ...

One emerging approach involves targeting liver sinusoidal endothelial cell (LSEC) glycolysis, which has been linked to inflammation and fibrosis. Quercetin, a naturally occurring flavonoid found ...

THE LIVER plays a fundamental role in regulating metabolism, integrating signals from the gut and adipose tissue to manage nutrient processing and storage. As the first organ to receive nutrient-rich ...

In a mouse model of MASH induced by an FFC diet, integrin β1 (ITGβ1) present in lipotoxic EVs mediates monocyte adhesion to liver sinusoidal endothelial cells, thereby exacerbating hepatic ...

Chronic liver disease is a cluster of disorders associated with complex haemodynamic alterations, which is characterised by structural and functional disruptions of the intrahepatic and extrahepatic ...