Liver fibrosis is a major global health concern, developing as a result of chronic liver diseases (CLDs) such as viral ...

LSECs are lining the liver sinusoids, a position that puts them in direct contact with antigens in the blood. This location, combined with their extraordinary clearance and tolerogenic function ...

Topas Therapeutics today announced the publication of data highlighting the ability of its proprietary antigen-coupled nanoparticles' to achieve tolerance induction in relevant autoimmune disease ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type ...

Hitting a plateau after a steady run of weight loss has derailed many health and fitness plans. But what if you could flick a ...

Hepatic stellate cells are located along the specialized blood capillaries of the liver, known as sinusoids. They are known to drive liver fibrosis, but their actual physiological functions and ...

The perfusion moves around these tissues, which recapitulate the liver sinusoidal structures. Our Multi-chip Barrier plates also feature 12-wells per plate. They can support insert-based barrier ...

Subsequently, hemodynamic changes post-PVL enhanced the expression of Piezo-1 in liver VECs and sinusoidal endothelial cells. Additionally, the authors showed that Yoda-1 (a specific agonist of ...

Once in the liver, the islets lodge in the small blood vessels called sinusoids, where they take up oxygen and nutrients from the surrounding tissue while new blood vessels form over the course of ...