LSECs are lining the liver sinusoids, a position that puts them in direct contact with antigens in the blood. This location, combined with their extraordinary clearance and tolerogenic function ...

Topas Therapeutics today announced the publication of data highlighting the ability of its proprietary antigen-coupled nanoparticles' to achieve tolerance induction in relevant autoimmune disease ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type ...

Publication supports Topas’ approach to generating immune tolerance through in vivo autoimmune disease model data in type 1 diabetes and multiple sclerosis Topas’ platform leverages the capability of ...

The earliest changes in stellate cells are likely to result from paracrine stimulation by all neighboring cell types, including sinusoidal ... abundant cell type in liver, are a potent source ...

To address this gap, researchers conducted a series of experiments ... Ammonia Build-Up Kills Liver Cells but Can Be Prevented Using Existing Drug Mar. 7, 2025 — High levels of ammonia kill ...

If you already have a liver condition such as cirrhosis, tell your doctor if you have any new or worsening symptoms. Symptoms of liver cancer are often quite vague and vary depending on where the ...

These updated guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) ...

The liver is a large, glandular, vital organ divided into two main lobes with a major role in metabolism, detoxification and production of chemicals necessary for digestion. The liver is ...