eLife

Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

Acetylation of lysine residues in the tail domain of histone H3 is well characterized, but lysine residues in the histone globular domain are also acetylated. Histone modifications in globular domain ...
The Lancet

A viral clonality evenness score to predict progression to adult T-cell leukaemia in asymptomatic carriers of human T-lymphotropic virus type 1 in Japan: a retrospectiv…

The implementation of VCE scoring in clinical practice could inform early pre-emptive therapeutic interventions, exclusively ...

Textbook view of NMDA receptor calcium signals upended by new findings

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...
eLife

Earliest Evidence of Elephant Butchery at Olduvai Gorge (Tanzania) Reveals the Evolutionary Impact of Early Human Megafaunal Exploitation

The role of megafaunal exploitation in early human evolution remains debated. Occasional use of large carcasses by early hominins has been considered by some as opportunistic, possibly a fallback ...