In T cell cancers such as T cell lymphoblastic leukemia (TLL), this challenge arises from fratricide, CAR T cell self-destruction. 1–3 CAR T cells often share the same receptors as malignant T cells, ...

While most people who are infected with HTLV-1 do not exhibit any symptoms, up to 5% of infected people will develop a type of leukemia called adult T-cell leukemia/lymphoma or a chronic neurological ...

Treatment of B-cell Acute Lymphoblastic Leukaemia has improved thanks to CAR-T therapies, but relapse is still very common.

Patients with acute myeloid leukemia who relapse after stem cell transplantation have just a small chance of survival: doctors can give them additional donor T cells to fight the cancer, but only ...

The first patients have been dosed in a trial of CAR T therapy in relapsed/refractory T cell acute lymphoblastic leukemia or ...

Previously reported Phase 1/2 data on WU-CART-007 demonstrated clinically manageable safety and evidence of anti-leukemic activity with an ...

B-cell Acute Lymphoblastic Leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most common childhood cancer, making up 35% of pediatric cancer cases, but it ...

Using human T cells and leukemia cells in specialized mouse models ... of Colorado Hospital and Children's Hospital Colorado – which see more than two million adult and pediatric patient visits yearly ...