The ACC/AHA Task Force on Clinical Practice Guidelines (Task Force) continuously reviews, updates, and modifies guideline methodology on the basis of published standards from organizations including ...

Studies about tenecteplase are emerging and, globally, more than 20 trials have been completed or are ongoing. The phase 3 trials AcT (Intravenous Tenecteplase Compared With Alteplase for Acute ...

The central antihypertensive action of clonidine was established by Sattler and van Swieten 1 in 1967. In their report, they described how this α 2-adrenergic agonist produced a depressor effect when ...

BACKGROUND: Viral cardiac infection represents a significant clinical challenge encompassing several etiological agents, disease stages, complex presentation, and a resulting lack of mechanistic ...

A comprehensive literature search was conducted from September 14, 2022, to November 22, 2022, encompassing studies, reviews, and other evidence on human subjects that were published in English from ...

Aim: This executive summary of the clinical practice guideline for the evaluation and diagnosis of chest pain provides recommendations and algorithms for clinicians to assess and diagnose chest pain ...

Methods and Results— Among 3006 offspring participants in the Framingham Heart Study free of CVD (mean age, 46 years at baseline), there were 129 hard coronary heart disease (CHD) events and 286 total ...

Beginning in this issue of Circulation, we present two new features designed to enhance the transfer of information to our clinician readers. First, you will notice that the cover includes a new box ...

As early as 1699, Chemineau described a heart composed of 2 auricles but only 1 ventricle.1 The univentricular heart has since fascinated the medical community. Unique in its complexity and scope, the ...

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a multifunctional ...

The interesting results of Ciaccio et al 15 may be seen as an attempt to support the notion that as AF becomes persistent, it increasingly depends on drivers localized within atrial regions outside ...

Although mechanistic pathways have been discovered, it is unknown how these and as of yet unknown mediators of preeclampsia can impact fetal heart development and their long-term consequences in the ...