Rationale:Recent evidence indicates that a few human microRNAs (miRNAs), in particular hsa-miR-199a-3p and hsa-miR-590-3p, stimulate proliferation of cardiomyocytes and, once expressed in the mouse ...

Measurement of blood pressure (BP) in the upright posture is recommended by all hypertension guidelines to detect orthostatic hypotension especially in elderly patients. 1 However, a number of studies ...

Statins are powerful lipid-lowering drugs that inhibit cholesterol biosynthesis via downregulation of hydroxymethylglutaryl coenzyme-A reductase. 1 They are largely used in patients with or at risk of ...

Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. During atherogenesis, vascular smooth muscle (VSM) cells migrate to populate ...

Background—MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular ...

Background— The ability to derive human induced pluripotent stem (hiPS) cell lines by reprogramming of adult fibroblasts with a set of transcription factors offers unique opportunities for basic and ...

Resistant hypertension is defined as failure to achieve goal blood pressure (BP) <140/90 mm Hg (or <130/80 mm Hg in patients with diabetes mellitus or chronic kidney disease) in patients with ...

The Editors of Circulation: Cardiovascular Quality and Outcomes are pleased to announce a new Patient or Caregiver Viewpoint section in the Journal. Viewpoints will be authored by patients or their ...

Increased renin gene expression along with hypertrophy of JGCs is found during long-term, enhanced renin release. In addition to the hypertrophy of juxtaglomerular cells, the abovementioned ...

In this issue of Circulation, van Loosdregt et al 7 performed a comprehensive inventory of cytokines, chemokines, and chemokine receptors expressed in human arteriosclerotic versus referent ...

The homeostasis model assessment (HOMA) index [fasting plasma glucose (mg/dL)×insulin (μU/mL)/405] was calculated from fasting glucose and insulin level as a marker of insulin resistance. 19 Insulin ...

In this issue of Circulation: Cardiovascular Interventions, Wasfy et al 13 present information that begins to address this gap in knowledge. The authors conducted a comprehensive medical record review ...