Nearly every modern guideline (from the World Health Organization to the FDA) requires systematic reviews as the foundation ...

Abstract Purpose We conducted a randomized controlled trial (SURF-RCT) to evaluate the efficacy of surgery versus radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Simultaneously, ...

Real-world evidence on infection risks from multiple sclerosis treatments remains limited, with inconsistent findings ...

Tumor necrosis factor inhibitor use in patients with IMIDs did not increase the risk of de novo heart failure or worsen existing heart failure.

A new protocol published in BMJ Open outlines the PERTH trial, a randomized controlled study testing whether a four-week ...

Despite observational evidence supporting a low-dose approach to antihypertensive therapy in the old and frail, a randomized prospective trial finds no clear benefits for doing so.

A new global systematic literature review and meta-analysis has shown that herpes zoster vaccination, used to prevent shingles, is associated with a statistically significant lower risk of heart ...

The absolute rate difference ranged from 1.2 to 2.2 fewer events per 1,000 person-years among all vaccinated adults.