For AI tools making high-stakes clinical decisions, well-designed, prospective RCTs must be the gold standard.

Recruiting patients from lower-income countries is associated with higher placebo response rates in rheumatoid arthritis trials, a recent study finds.

Rationale and study design of the KOV-HIPEC-04: A phase III randomized controlled trial in primary stage three and four ovarian cancer after interval cytoreductive surgery (FOCUS).

Randomized control trials are the most rigorous way of determining whether a cause-effect relationship exists between treatment and outcome and assessing a treatment’s cost-effectiveness.

A cluster-randomized design was chosen because the intervention was implemented hospital-wide; a crossover design was chosen to improve the power and statistical efficiency of the trial.