Late-onset Alzheimer's disease (LOAD) is the most common form of dementia, with symptoms appearing after age 65. Since ...

Complement, a part of the innate immune system that functions both in the brain and throughout the body, enhances the body's ability to fight pathogens, promote inflammation and clear damaged cells.

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

“Nipocalimab appears to have an effect on lowering but not completely suppressing complement activation, and may thus potentially reduce NMJ damage, while still allowing the complement pathway ...

How the Complement System Affects Your Kidneys When you have C3 glomerulopathy, your alternative complement system is overactive.

In this article, ACROBiosystems discusses how the complement cascade and it's various components could potentially be leveraged for therapeutic potential in COVID-19, cancer and general inflammation.

C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) are two rare kidney diseases. They’re both driven by activity of the complement system ...

The complement system, of which CFH is a modulator, is dysregulated in patients with these risk variants, and results in amplification of aberrant inflammatory responses in the eye.

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system -- a group of proteins ...

Current treatment methods for C3 glomerulopathy (C3G) help support kidney function and suppress immune system activity. Emerging therapies interrupt the proteins responsible for disease activity.