Chimeric antigen receptor (CAR) T cells directed against CD19 have demonstrated efficacy in treating active lupus in both human and mouse lupus. However, a significant limitation of this approach is ...

Background The neutrophil-to-lymphocyte ratio (NLR) is known to be associated with a poor outcome in patients with chronic kidney disease (CKD). Several studies have reported that NLR is closely ...

Objective We sought to examine – for the first time – the clinical manifestations of cutaneous (CLE) and systemic lupus erythematosus (SLE) among patients in Nicaragua as well as socioeconomic ...

Background The prevalence rate of SLE in previous reports has widely varied by as much as 12-fold over the years, which is likely due to variabilities in study populations, case definitions, and case ...

Алибекова Гульжан, A147Алибекова Гульжан, A147 Abeysinghe Duminda, A148 Abramkin Anton, A102 Accelerating Medicines Partnership (AMP) Ra/sle, A124 Acevedo-Vásquez Eduardo, A142 Acharya Mridu, A59 ...

Abdelkefi Cherifa, P121Abdelkefi Cherifa, P121 Abdelmoumen Karim, P80 Abheiden Carolien, O7 Abid Yosr, P50 Abida Houssem, P32, P121 Abramova Nadezda, P102 Abramson Jeremy, P105 Abreu Catarina, O41 ...

Conclusions This study is the first demonstration of a regulatory effect of HDL on the adaptive immune system of SLE patients. Here we show that HDL can decrease T cell proliferation, which is not ...

Conclusions An initial decrease followed by a subsequent return in circulating short-lived plasma cells and plasmablasts upon treatment for active SLE portended renal flares, indicating a need for ...

Background Lupus nephritis (LN) has been identified as a major risk factor for the mortality in patients with systemic lupus erythematosus (SLE). We investigated the predictors of end-stage renal ...

Purpose Autoantibodies (AAB) targeting self-antigens can be found in two clinically and immunologically opposing diseases, autoimmune diseases and cancer. While in autoimmune diseases, the immune ...

Background Lupus is an autoimmune disease characterized by antibodies directed against nuclear components that induce immune complex-mediated injury to multiple organs. Underlying lupus is the ...

Purpose to identify preconception risk factors and serum biomarkers associated with adverse pregnancy outcomes (APOs) in patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome ...