Axon pathology in some neurodegenerative disorders involves mechanisms that are related to those occurring during Wallerian degeneration after axon injury. Wallerian degeneration has significant ...

Wallerian degeneration is a subject of major interest in neuroscience. A large number of genes are differentially regulated during the distinct stages of Wallerian degeneration: transcription ...

Figure 2: Normal axon degeneration in mice requires DLK in vitro and in vivo. Figure 3: JNK promotes Wallerian degeneration and is critical in the first 3 h after axotomy. JNK could commit axons ...

Principal author Zhigang He and colleagues at the Children's Hospital and Harvard Medical School, Boston, and Stanford University, California, examined the role of the proteasome in Wallerian ...

Macrophages enter to clear the resulting debris. The nerve distal to the injury degenerates in a process known as Wallerian degeneration. [15] A less severe degree of degeneration also occurs in ...