To prove that NAD plays a role in slowing Wallerian degeneration, Araki mutated Nmnat1 amino acids that are essential for this activity, and sure enough, these mutants failed to protect axons. In fact ...

Wallerian degeneration is a subject of major interest in neuroscience. A large number of genes are differentially regulated during the distinct stages of Wallerian degeneration: transcription ...

Wallerian degeneration—an active process that is similar to apoptosis—seems to drive axonal loss in patients with MS 26 and EAE mice. 131 This dying-back process can be attenuated in mice by ...

In the present study, however, Zhai, Wang, and colleagues extend the observations beyond Wallerian degeneration by showing that MG132 also prevents degeneration in whole axons deprived of nerve growth ...

WHEN a peripheral nerve is cut, the portion of the nerve distal to the point of section undergoes a series of changes characteristic of Wallerian degeneration. The axon and, later, the myelin ...

The studies are reported in the Journal of Neuroscience, in a paper entitled “Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration ...

Wallerian degeneration occurs distal to the injury site. Because the connective tissues are intact, typically recovery is complete. Similar injury Results from compression by tumors or masses.