Oligodendrocytes (OLs) differentiate to myelinate central nervous system (CNS). CNS myelination by OLs is important not only for saltatory conduction of action potentials but also for trophic support ...

The central concept underlying ideas on the pathogenesis of multiple sclerosis is that inflammatory events cause acute injury of axons and myclin. The phases of symptom onset, recovery, persistence, ...

Surrounding the individual axons is the collagenous tissue layer known as the endoneurium. This layer resists longitudinal stress and contributes to the formation of the endoneurial tube. The fascicle ...

Saltatory conduction — the process by which action potentials propagate along myelinated nerves — depends on the fact that voltage-gated Na + channels form clusters at the nodes of Ranvier, between ...

William M. Spees, Tsen-Hsuan Lin, Peng Sun, Chunyu Song, Ajit George, Sam E. Gary, Hsin-Chieh Yang, Sheng-Kwei Song Proceedings of the National Academy of Sciences of the United States of America, Vol ...

University of Alabama at Birmingham researchers, for the first time ever, have achieved patch-clamp studies of an elusive part of mammalian myelinated nerves called the Nodes of Ranvier. At the nodes, ...

A team has shown that the axons of auditory neurons in the brainstem which respond to low and high-frequency sounds differ in their morphology, and that these variations correlate with differences in ...

Jianguo Gu, Ph.D., Edward A. Ernst Endowed Chair and professor in the Department of Anesthesiology and Perioperative Medicine, is the latest winner of the School of Medicine’s Featured Discovery. This ...