A New York Times health reporter explains what clinical trials are, why they are important and how they can help inform us.

Covariate-adaptive randomization represents an advanced methodology in the design of clinical trials, ensuring a balanced distribution of prognostic factors among treatment groups. This approach ...

For more than three decades, researchers Christine Stabell Benn and Peter Aaby from the Bandim Health Project have conducted ...

The equipoise randomization strategy allowed patients to indicate a preference to which of the level 2 options they would accept or refuse. Only 1% of the cohort would accept all 7 treatment options.

The aim of this research therefore was to streamline the understanding of typical causal structures in both randomized and nonrandomized clinical trials in oncology, presenting concise guidelines for ...

We are witnessing an increasing demand for rapid, rigorous, and generalizable evidence to inform health care systems’ learning and address inefficiencies in the current clinical trials landscape.

The bacille Calmette–Guérin (BCG) vaccine has immunomodulatory “off-target” effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19). In this international, ...

Glutamine is thought to have beneficial effects on the metabolic and stress response to severe injury. Clinical trials involving patients with burns and other critically ill patients have shown ...

Point-of-Care Urine Metabolomics Test to Diagnose Colorectal Cancers in Low- and Middle-Income Countries: A Pilot Controlled Trial in Southwestern Nigeria Our findings support the efficacy of TA in ...

The SOL-R registrational trial (NCT06495918) of OTX-TKI (AXPAXLI) by Ocular Therapeutix has reached its randomization target of 555 patients.