Predicting a protein's structure from its amino acid sequence is a 'holy grail' for the structural biology community. In spite of decades of effort, it remains an extremely difficult problem both ...

Learn about our Editorial Policies. While AlphaFold and the subsequent AI revolution in biology garnered a lot of attention, the foundational bricks for the strides made in protein structure and ...

Because a protein’s structure helps determine its biological function, the new structures, along with those available from cryo-EM, could revolutionize biology and drug discovery. To be useful ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the ...

Imagine standing on a vast, dark plain. Without light, you cannot see dips and rolls in the grass or make out hills and ...

Biophysicists have elucidated why unexpected structures can sometimes arise during protein design. Artificially designed proteins are usually based on building blocks that obey strict rules of ...

Our research focuses on studies on the molecular structure and mechanism of proteins, recently mostly on the endoplasmic ... We also collaborate on various structural biology projects with local ...

Rohini Subrahmanyam is a biologist-turned-science-writer with a background in neuroscience and developmental biology. She has written ... nanoseconds to microseconds for a protein to morph along its ...

"AlphaFold has transformed structural biology by providing accurate predictions of protein structures ... accurately predict the three-dimensional structure of IDPs, it can predict the distances ...