Researchers have unveiled the first real look at a mitochondrial protein strongly linked to Parkinson's disease, revealing ...

Because a protein’s structure helps determine its biological function, the new structures, along with those available from cryo-EM, could revolutionize biology and drug discovery. To be useful ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

Imagine standing on a vast, dark plain. Without light, you cannot see dips and rolls in the grass or make out hills and ...

Biophysicists have elucidated why unexpected structures can sometimes arise during protein design. Artificially designed proteins are usually based on building blocks that obey strict rules of ...

Rohini Subrahmanyam is a biologist-turned-science-writer with a background in neuroscience and developmental biology. She has written ... nanoseconds to microseconds for a protein to morph along its ...

"AlphaFold has transformed structural biology by providing accurate predictions of protein structures ... accurately predict the three-dimensional structure of IDPs, it can predict the distances ...

In a paper published in PNAS, researchers at King's College London and the University of Washington describe the unique 3D structure of this protein, which is now being used to develop cancer drug ...

As such, their structure can generally be ... oligomorphism in computationally designed protein assemblies, Nature Structural & Molecular Biology (2025). DOI: 10.1038/s41594-025-01490-z ...