The New England Journal of Medicine

Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A

The goal of gene therapy for patients with hemophilia A is to safely impart long-term stable factor VIII expression that predictably ameliorates bleeding with the use of the lowest possible vector ...
Nature

A quantitative model of transcription factor–activated gene expression

In eukaryotic cells, environmental stimuli commonly lead to activation of transcription factors and alteration of gene expression levels 1. Many transcription factors control multiple genes, but these ...
Nature

Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer

Venous thromboembolism (VTE) is a common complication of cancer (Baron et al, 1998; Lee and Levine, 2003). Since the first description of an association between VTE and cancer by Trousseau (1868), ...
ascopubs.org

Reduced integrin alpha3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung.

Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer. The ratio of integrin alpha3/beta-actin expression ranged from 0 to 5.87 (mean was 0.80; ...
News Medical

Monitoring the presence of bovine meat and milk factor protein expression may help identify people at risk of colorectal cancer

Bovine meat and milk factors (BMMFs) - initially identified by de Villiers et al. in 2014 - represent a class of infectious agents in beef and cow's milk that have been linked to the development of ...
TMCnet

Flipping the script: Scripta Therapeutics raises $12M to find disease-modifying drugs that alter transcription factor activity

Scripta's unique approach is based on the concept that transcription factors, the master controllers of gene expression, are core drivers of disease and act as detailed and dynamic maps of the ...