Research appears in PLoS ONE, and the scientists are working to improve sensitivity. Scientists at the Southwest Foundation for Biomedical Research (SFBR) developed a technique using llama antibodies ...
Background. Only Clostridium botulinum strain IBCA10-7060 produces the recently described novel botulinum neurotoxin type H (BoNT/H). BoNT/H (N-terminal two-thirds most homologous to BoNT/F and ...
Botulinum neurotoxins (BoNTs) are a family of highly potent proteins produced primarily by Clostridium species. These toxins induce botulism, a severe paralytic illness resulting from their ability to ...
Published in Nature Communications, the study, titled, "Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2," reveals a novel 3D structure that shows how BoNT/E ...
Irvine, Calif. - February 27, 2020 - New study reveals potential for developing novel antibody-based antitoxins against botulinum neurotoxins (BoNTs), including the most commonly used, yet most toxic ...
If Russian opposition leader Alexey Navalny was, as German leaders say, poisoned with the deadly Soviet-era Novichok neurotoxin, it would once again highlight the willingness of the Kremlin to deploy ...
Harvard researchers have evolved botulinum neurotoxins — commonly known as botox — to selectively target different proteins for the first time, presenting new opportunities for the potential treatment ...
Botulism is a potentially fatal paralytic disease caused by the action of botulinum neurotoxin (BoNT) on nerve cells. There are 7 known serotypes (A–G) of BoNT and up to 40 genetic variants.
Researchers have identified a compound that strongly inhibits botulinum neurotoxin, the most toxic compound known. That inhibiting compound, nitrophenyl psoralen (NPP), could be used as a treatment to ...
Currently there's no treatment for botulism once the toxin gets into neurons. This novel treatment neutralized the toxin with a second, modified botulinum toxin that delivered a mini antibody into the ...
The toxin complex with its 14 components. The toxin itself is colored pink and sits at the top of the complex. The structure consists of tens of thousands of atoms, and here we only show the surface ...
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