Obesity arises from an imbalance between adipogenesis and adipocyte thermogenesis. IL-27 suppresses adipogenesis, prevents weight gain, and improves glucose and lipid metabolic homeostasis in high ...

Aged individuals and astronauts experience bone loss despite rigorous physical activity. Bone mechanoresponse is in-part ...

Despite the high prevalence and morbidity of osteoarthritis (OA), an effective treatment for this disease is currently lacking. Restoration of the diseased articular cartilage in patients with OA ...

New stem cell therapies may result from a novel method that McGill researchers have created for mechanically modifying stem cells, which has not yet reached its full therapeutic potential.

A new technique developed by McGill researchers for mechanically manipulating stem cells could lead to new stem cell treatments, which have yet to fulfill their therapeutic potential. Stem cell ...

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

(A) The infection of Ad-Shh in MSCs (fluorescence microscope, × 100). (B) Validation of the expression of Shh by Ad-Shh in MSCs (Western blot). (C, D) The effects of Shh on BMP9-induced ALP ...

Our blood consists of many cell types that develop through different stages from a precursor type—the blood stem cell. An ...

Discover how blood stem cells release IL-10 to regulate inflammation and protect bone marrow, offering new therapeutic ...

The pluripotent and multipotent stem cells are found in the bone marrow, which can differentiate into any tissue in the body.

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December 2024, immediately following the approval of the world's first mesenchymal stromal cells clinical trial, the U.S. FDA ...