Lariocidin is a newly discovered antibiotic from soil bacteria. It targets the bacterial ribosome, defeating resistant ...

Researchers discovered lariocidin, a lasso peptide antibiotic that kills multidrug-resistant bacteria by binding a novel ...

Only recently has the ribosome—one of the oldest molecular machines in evolutionary terms—been recognized as an active ...

However, the infection did modify the underlying molecular structure of the ribosome, leading to increased poxvirus protein translation. Genetic knockout screens coupled with metabolic assays ...

A central tenet of biology has long held that each amino acid added to a peptide chain is specified by an RNA message as it threads its way through the ribosome. But Howard Hughes Medical Institute ...

A natural antibacterial molecule shows clinical promise. Its unusual binding site is on an excellent target: ...

The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

The researchers visualized translation, including ribosome pauses, by using the intensity of GFP-tagged antibodies on the polypeptide to measure polypeptide elongation. As Tanenbaum and his team ...

A previously unknown kind of ribosome is responsible for folding sperm proteins, which decay before fertilization if prepared by other ribosomes. Dan is a News Editor at The Scientist. He writes and ...

A small molecule shaped like a lasso may be a powerful tool in the fight against infectious diseases, according to a new study in Nature co-authored by University of Illinois Chicago researchers.

Although only a few rRNA molecules are present in each ribosome, these molecules make up about half of the ribosomal mass. The remaining mass consists of a number of proteins — nearly 60 in ...

Nobel prizewinner Venki Ramakrishnan talks to New Scientist about the recent breakthroughs in our knowledge of what causes ...